Figure 9.

PKA inhibition does not affect the average mIPSCs amplitude in pyramidal neurons from all groups. A, Spontaneous inhibitory events recorded from neurons from a pseudo-trained rat (left) and a trained rat (right), before (top traces) and after (bottom traces) application of the PKC blocker H89 dihydrochloride. The amplitude of events in both neurons is not modified by the blocker. B, Amplitude histograms of the two neurons recorded in A. H89 dihydrochloride does not have a notable effect on the amplitude distribution in the two neurons (bottom histograms). C, The average amplitude if the inhibitory synaptic events is not modified in the three groups, and the learning-induced increase in the average amplitude remains (*p < 0.05). Data taken from eight trained, seven naïve, and six pseudo-trained rats. D, Although H89 dihydrochloride modifies the amplitudes of events in the three groups, it appears to have a bidirectional effect, as a result of which no net change occurs in the average values.