Fig. 3.

Diagnostic plots for microglia SNP sets for ENIGMA (N = 13,163; left: β = −26.9, P = 0.016, N_SNPS = 60) and UK Biobank (N = 9707; right: β = −0.05, P = 0.027, N_SNPS = 61), both constrained to the P-threshold < 0.01. Each SNP is plotted by coefficient in the risk score (x axis) versus estimated effect size for HV in the testing dataset (y axis). The solid black line shows the effect size estimate for the risk score on HV in each of the testing datasets. Grey bar represents 95% confidence intervals.