Table 1.
Meta-analysis for association between AD-RPS and hippocampal volume (HV) across a progressive series of P-thresholds (PT > 0.001–0.5). All AD SNPs represents an AD-RPS derived from common SNPs (MAF > 0.01) across the whole genome (excluding APOE and MHC region). Microglia loci represents all common SNPs located in proximity to 56 genes implicated in the microglia – meditated innate immunity network. SNPs represents the number of AD associated risk variants considered at each P-threshold. Results in bold reflect significant effects in the meta-analysis.
| ENIGMA (N = 13163) |
UKBB (N = 9707) |
Meta-analysis (Z/P) |
||||||
|---|---|---|---|---|---|---|---|---|
| PT | All AD SNPs | Microglia SNPs | All AD SNPs | Microglia SNPs | All AD SNPs | Microglia SNPs | ||
| 0.001 | 1479 | 16 | 1598 | 16 | 0.679 | 0.497 | −2.344 | 0.019 |
| 0.005 | 5159 | 33 | 5723 | 34 | −0.079 | 0.937 | −2.495 | 0.013 |
| 0.01 | 8742 | 60 | 9755 | 61 | −1.198 | 0.231 | −2.152 | 0.031 |
| 0.1 | 45,698 | 221 | 52,308 | 234 | −1.876 | 0.061 | 0.111 | 0.911 |
| 0.2 | 70,810 | 307 | 81,407 | 326 | −2.128 | 0.033 | 0.070 | 0.944 |
| 0.5 | 117,446 | 473 | 136,598 | 529 | −2.070 | 0.038 | −0.249 | 0.804 |