Figure 3.

A, Accelerated reexpression of MBP in the corpus callosum of Ptprz-deficient mice after cuprizone-induced demyelination. Images show the dorsal corpus callosum. Coronal brain sections from wild-type (+/+) and Ptprz-deficient (−/−) mice were immunohistochemically analyzed using a specific polyclonal antibody against MBP (anti-MBP). Scale bars, 100 μm. B, Quantification of anti-MBP staining in the dorsal corpus callosum. Open circles, Wild-type mouse; closed circles, Ptprz-deficient mouse. n = 10 for each group. *p < 0.05, two-way ANOVA with Bonferroni post hoc test.