The solid line represents the estimated quadratic relationship between neocortical 5-HT2AR-specific radiotracer binding (BPP) and subcortical (caudate, putamen, and thalamus) 5-HTT-specific radiotracer binding (BPND). The 95% confidence interval is represented by the thin lines. Black dots, Pre-RYGB participants; crosses, lean participants; open triangles, post-RYGB participants.