Figure 6.

Elimination of TRPM2 in APP/PS1 mice does not change age-related hypoactivity or anxiety. A, Exploratory activity in the open field test of 3- to 15-month-old mice. At 15 months, carriers of APP/PS1 transgenes show decreased locomotion compared with noncarriers. B, Representative elevated plus maze exploration of 15-month-old mice. Bars represent the percentage of time spent by the four genotypes in the Open Arm of the maze. *p < 0.05. N for WT = 8–12, N for TRPM2^−/− = 7–10, N for APP/PS1 = 10 or 11, N for TRPM2^−/−/APP/PS1 = 10 or 11.