Figure 6.

Cortical cooling disrupted the slow-wave pattern and evoked rhythmic depolarizing events within PO neurons in deeply anesthetized mice. A–C, An example of simultaneously recorded EEG (contralateral M1 and S1), LFP (ipsilateral S1), and intracellular activities from the thalamic PO neuron in control (A), during cooling (B), and after recovery (C). Bottom traces show one slow-wave cycle in control (left) and cooling-triggered intracellular EPSPs correlated to LFP spikes (right). A1–C1, Averaged EEG, LFP, intracellular activity, and EPSP autocorrelograms (n = 6 recordings from 6 mice). EEG, LFP, and intracellular activities were averaged against (triggered by) extracted EPSPs. Before averaging in a group, each autocorrelogram was normalized to 100%. A1, Control. B1, Cooling. C1, Recovery. In all panels, the positive part of SEM is shown with gray (negative part is not shown).