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. 2015 Sep 23;35(38):13160–13170. doi: 10.1523/JNEUROSCI.3123-14.2015

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Copyright © 2015 the authors 0270-6474/15/3513160-11$15.00/0

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Figure 3. — CCK-induced activation of CCK2Rs mediates DPI. A, Sample traces of IPSCs before and after repetitive depolarization in the presence of the CCK2R antagonist LY-225910 (1 μm; top) and summary data showing that LY-225910 completely blocks potentiation of GABA synapses following repetitive depolarization (bottom; n = 7). Calibration: 25 pA, 10 ms. B, Summary data showing the percentage change in IPSC amplitude following repetitive depolarization in the following conditions: control (n = 12), LY-225910 (n = 7), lorglumide (CCK1R antagonist; 1 μm; n = 7), and GDPβS (1 mm; in the patch pipette; n = 6). **p < 0.01 versus baseline.