Figure 11.
A diagram of the proposed model for the role of CCL2-mediated macrophage activation following preconditioning SNI. A, An axotomy at the sciatic nerve produces injury signals that are retrogradely transmitted to neurons in the DRGs. B, The injury signals induce initial activation (dotted black arrows) of multiple RAGs. Activation of a particular RAG (RAGX) may be specifically linked to the production of CCL2 by DRG neurons (dotted blue arrows). C, Activated macrophages (M2-polarized) expressing CCR2 provide proregenerative factors resulting in the amplification and maintenance (thick red arrows) of RAGs. Changes in the tip morphology of central axons reflect the enhanced regenerative capacity of DRG neurons.