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. 2015 Oct 28;35(43):14501–14516. doi: 10.1523/JNEUROSCI.1056-15.2015

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Copyright © 2015 the authors 0270-6474/15/3514501-16$15.00/0

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Figure 9. — Reduced vacuolation in the corpus callosum of aged Aspa^nur7/nur7 mice. HE staining on sagittal paraffin-embedded brain sections demonstrate a reversible phenotype in the corpus callosum of Nat8L^+/+/Aspa^nur7/nur7 and Nat8L^+/−/Aspa^nur7/nur7 mice. At the age of P21, Nat8L^+/+/Aspa^nur7/nur7 (C, G) and Nat8L^+/−/Aspa^nur7/nur7 (D, H) mice show a clear vacuolation in the white matter of corpus callosum compared with Nat8L^+/+/Aspa^nur7/+ (control) (A) and Nat8L^−/−/Aspa^nur7/nur7 (B) mice. At the age of 1 year, only a few small vacuoles were evident in this brain region and the histology appeared almost normal in Nat8L^+/+/Aspa^nur7/nur7 (E, I) and Nat8L^+/−/Aspa^nur7/nur7 (F, J) mice. Images G–J show higher magnifications of the images C–F. Scale bars: A–F, 200 μm; G–J: 100 μm.