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. 2015 Nov 18;35(46):15419–15429. doi: 10.1523/JNEUROSCI.1449-15.2015

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Copyright © 2015 the authors 0270-6474/15/3515419-11$15.00/0

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Figure 4. — Balance between AVP and α-MSH in the MnPO determines the Tb. Change in core temperature of animals infused into the MnPO with (A) MTII (n = 4) versus Ringer (n = 5) at ZT 2–5 (B) SHU9119 (n = 6) versus Ringer (n = 7) at ZT 18–20.3, (C) AVP (n = 4) versus Ringer (n = 7) at ZT 18–21, (D) V1a-ANT (n = 4) versus Ringer (n = 5) at ZT 2–5. Significant differences are indicated by Bonferroni's post hoc for individual time points are indicated with an asterisk. E, Simultaneous infusion of V1a-ANT+MTII (n = 5) at ZT 2 (n = 5) compared with the respective single infusions. Significant differences between V1a-ANT+MTII versus Ringer are represented as a, between V1a-ANT+MTII versus MTII are noted as b, and between V1a-ANT+MTII versus V1a-ANT as c. F, Simultaneous infusion of V1a-ANT+ SHU9119 at ZT 18 (n = 4) compared with the SHU9119 single infusion. Significant differences between V1a-ANT+SHU9119 vs SHU9119 are indicated with an asterisk. No significant differences between V1a-ANT+SHU9119 versus Ringer were found. Temperature data were collected every 10 min. Dotted rectangles indicate the infusion period, the blue dotted box indicates SHU9119 infusion period, and the red dotted box indicates V1a-ANT + SHU9119. *p < 0.05, **p < 0.01, ***p < 0.0001.