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. 2015 Nov 18;35(46):15339–15352. doi: 10.1523/JNEUROSCI.0861-15.2015

Figure 8.

Figure 8.

Connexin 43 hemichannels modulation of slow oscillations requires adenosine A1 receptor function. A, Example of MC recording with successive application of the adenosine A1 receptor blocker DPCPX, followed by Gap26 (combined to DPCPX). B, Left, Mean effect of Gap26 treatment on UP state amplitude, in presence or absence of DPCPX. **p = 0.005 (Mann and Whitney U test; n = 8 for both control and DPCPX conditions). Right, Effect of Gap26 treatment on UP state amplitude for individual cells in the presence of DPCPX (p > 0.99, two-tailed Wilcoxon matched-pairs signed rank test). C, Application of the adenosine A1 receptor antagonist DPCPX occluded the reducing effect of Gap26 on UP state amplitude in MCs. *p = 0.01 (effect of Gap26 compared to control condition, without DPCPX; two-tailed Wilcoxon matched-pairs signed rank test); ##p = 0.006 (two-way ANOVA, interaction).