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. 2015 Dec 16;35(50):16479–16493. doi: 10.1523/JNEUROSCI.1585-15.2015

Figure 5.

Figure 5.

Impairment in dendritic growth precedes that in EPSCs in NRG2-depleted GCs. A, Representative dendritic arbors reconstructed from confocal images of control and Dox-treated newborn GCs at 10 and14 dpi. Scale bar, 50 μm. B, Sholl analysis of dendritic complexity at 10 and 14 dpi showing the intersection numbers per 10 μm radial unit distance. The complexity was significantly reduced by NRG2 depletion at both 10 and 14 dpi (control vs Dox, F(1,35) = 19.1 at 10 dpi, F(1,67) = 42.5 at 14 dpi, p < 0.001 for both dpi's, RM one-way ANOVA). C, Cumulative distributions of dendrites at 10 and 14 dpi. **p < 0.01; ***p < 0,001 by K-S test. D, Developmental increases of total dendritic lengths in control and Dox-treated GCs. ***p < 0.001 (t test).