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Increased neuropathic pain behavior in Slack−/− mice. A, B, Paw-withdrawal latencies of Slack−/− and WT mice after mechanical stimulation in the SNI model (n = 8/genotype; A) and the paclitaxel model (2 mg/kg, i.p., for 5 consecutive days; n = 8–9/genotype; B) of neuropathic pain. Slack−/− mice demonstrated increased mechanical hypersensitivity compared with WT littermates. *p < 0.05, WT versus Slack−/−, repeated-measures ANOVA with Bonferroni's post hoc test.
