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. 2015 Jan 21;35(3):920–935. doi: 10.1523/JNEUROSCI.2384-14.2015

Table 3.

Results of the fMRI picture-rating task during encoding contrast meaningful versus scrambled pictures

Whole brain analyses results
 ROI results based on the averaged estimates per cluster
N Post hoc tests
 Filtering steps
Region H Fmax Peak voxel MNI coordinates
 Sex x-valence category analyses for different subsets of valence categories
 ME sex neg
 ME arousal rating neg
 Arousal rating x-valence category
 ME valence rating neg
 Valence rating x-valence category
X Y Z Neg, neu, pos: p Neg, neu: p Neg, pos: p Pos, neu: p p d p r Neg, neu: p p r Neg, neu: p
Frontal lobe
    Paracentral lobule* L 19.7 −13.75 −30.25 40 49 8.9 × 10−10* 3.4 × 10−7* 5.2 × 10−9* 0.86 6.2 × 10−8* 0.42 0.0034 0.11 6.7 × 10−12* 5 × 10−4* −0.13 0.0075
    Precental gyrus 1 L 18.39 −57.75 5.5 0 17 5.3 × 10−8* 0.00011* 6.1 × 10−9* 0.13 2 × 10−5* 0.33 0.76 0.01 0.00033* 0.67 −0.02 0.021
    Precental gyrus 2* L 14.26 −46.75 0 4 6 2.1 × 10−7* 2.7 × 10−5* 1.6 × 10−7* 0.45 5.3 × 10−12* 0.54 0.00055* 0.13 4.5 × 10−11* 0.00026* −0.14 0.0059
    Precental gyrus 3* L 19.48 −35.75 −13.75 48 51 1.8 × 10−8* 0.00014* 6.7 × 10−10* 0.084 4.6 × 10−7* 0.39 6.1 × 10−6* 0.17 3.4 × 10−14* 0.0043 −0.11 8.1 × 10−5*
    Precental gyrus 4* L 15.73 −16.5 −11 76 10 6.9 × 10−8* 7.8 × 10−8* 5 × 10−5* 0.11 6.8 × 10−6* 0.35 0.069 0.07 1 × 10−6* 0.00073* −0.13 0.00013*
    Precental gyrus 5 R 14.8 60.5 8.25 4 5 1.9 × 10−7* 3.4 × 10−6* 1.3 × 10−6* 0.69 3.5 × 10−7* 0.4 0.079 0.07 3.1 × 10−7* 0.62 −0.02 0.046
    Precental gyrus 6† R 15.15 46.75 −2.75 52 6 6.1 × 10−7* 0.0024 2.9 × 10−8* 0.032 0.0025 0.24 0.28 0.04 6.9 × 10−6* 0.22 −0.05 0.0066
    Superior frontal gyrus R 19.19 8.25 2.75 64 47 3.6 × 10−9* 5.1 × 10−7* 5 × 10−8* 0.98 4.6 × 10−6* 0.36 0.14 0.06 3 × 10−5* 0.033 −0.08 0.0034
Parietal lobe
    Inferior parietal cortex L 14.31 −38.5 −82.5 28 9 1.3 × 10−7* 1.1 × 10−6* 2.6 × 10−6* 0.4 0.15 0.11 0.41 −0.03 0.53 0.21 −0.05 0.013
    Precuneus cortex L 18.27 −8.25 −49.5 52 65 8.5 × 10−9* 4.1 × 10−7* 3.5 × 10−7* 0.49 0.023 0.18 0.58 0.02 5.6 × 10−5* 0.11 −0.06 0.0065
    Superior parietal cortex L 13.86 −19.25 −46.75 68 7 3.7 × 10−7* 1.1 × 10−5* 1.4 × 10−6* 0.97 0.01 0.2 0.063 0.07 1.4 × 10−13* 0.076 −0.07 0.004
    Supramarginal gyrus 1 L 14.11 −63.25 −22 16 5 9.3 × 10−7* 0.00022* 2.9 × 10−7* 0.23 3.8 × 10−6* 0.36 0.03 0.08 2 × 10−10* 0.035 −0.08 0.24
    Supramarginal gyrus 2* L 15.37 −52.25 −27.5 20 16 7.7 × 10−8* 2.1 × 10−5* 1 × 10−8* 0.56 4.1 × 10−7* 0.4 0.0017* 0.12 4.7 × 10−16* 0.00081* −0.13 0.086
    Supramarginal gyrus 3 L 16.84 −60.5 −35.75 32 22 6.3 × 10−8* 1.2 × 10−5* 3 × 10−8* 0.53 0.00023* 0.29 0.89 0.01 0.0016* 0.027 −0.09 0.05
    Supramarginal gyrus 4* R 13.92 49.5 −27.5 28 11 4 × 10−7* 3 × 10−5* 3 × 10−7* 0.71 4 × 10−6* 0.36 8.6 × 10−6* 0.17 <1 × 10−16* 0.2 −0.05 0.064
Occipital lobe
    Cuneus cortex* L 14.95 −13.75 −77 20 19 1.3 × 10−7* 0.00012* 2.5 × 10−8* 0.19 3.4 × 10−10* 0.49 1.1 × 10−14* 0.29 2.9 × 10−12* 0.00046* −0.13 4.4 × 10−12*
    Lingual gyrus 1† L 16.36 −13.75 −55 −8 25 1 × 10−7* 0.0067 6 × 10−9* 0.0038 2.9 × 10−06* 0.37 6.4 × 10−12* 0.26 1.2 × 10−10* 0.0015* −0.12 1.1 × 10−11*
    Lingual gyrus 2 R 14.61 24.75 −49.5 4 5 5.2 × 10−7* 0.00049* 6.1 × 10−8* 0.12 0.33 0.07 6.1 × 10−7* 0.19 8.3 × 10−13* 0.0055 −0.11 1.3 × 10−6*
Cingulate cortex
    Cingulate cortex, caudal anterior division L 15.07 0 16.5 28 10 1 × 10−7* 3.4 × 10−7* 0.00012* 0.041 6.7 × 10−9* 0.45 0.55 0.02 0.24 0.48 −0.03 0.0099
    Cingulate cortex, Posterior division R 15.19 11 −27.5 40 16 7.2 × 10−8* 1 × 10−6* 3.2 × 10−6* 0.32 1.5 × 10−16* 0.65 0.024 0.08 1.3 × 10−12* 0.087 −0.06 0.13
Cerebellum
    Cerebellum cortex 1 L 21.77 −33 −57.75 −52 73 1.2 × 10−12* 1.1 × 10−8* 9.3 × 10−12* 0.58 8.9 × 10−8* 0.43 0.082 0.07 0.012 0.44 −0.03 0.00057*
    Cerebellum cortex 2* R 14.92 24.75 −44 −28 11 1.8 × 10−8* 1.7 × 10−6* 6.7 × 10−8* 0.91 3.5 × 10−5* 0.32 0.0098 0.1 0.00061* 0.00074* −0.13 4.4 × 10−6*
    Cerebellum white matter R 14.63 24.75 −46.75 −48 5 2.1 × 10−7* 1.6 × 10−5* 1.7 × 10−7* 0.69 0.074 0.14 0.19 0.05 0.3 0.45 −0.03 0.056
Temporal lobe
    Superior temporal gyrus†† L 19.23 −35.75 −2.75 −24 19 3.5 × 10−10* 1.3 × 10−8* 2.8 × 10−8* 0.85 1.4 × 10−6* 0.38 0.15 0.06 0.00071* 0.053 −0.07 0.00055*

The table gives an overview about all brain regions that showed a significant interaction effect for sex and valence category on whole-brain level. The post hoc tests revealed, that all but two regions (marked with†, precental gyrus 6 and lingual gyrus 1) showed a significant (p < 0.002) negative specific sex x-valence interaction. Regions marked with an asterisk (*) additionally survived all filtering steps of the ROI analyses. In these regions, additionally to the sex x-valence interaction effect, there was a significant main effect of sex for negative pictures and a significant correlation with valence or arousal rating of negative pictures. For all clusters, except the left paracentral lobule, this correlation was significantly stronger for negative in comparison to the neutral picture category, at least for one of the two ratings. The relevant significant p values for the filtering are printed in bold. p < 0.002 are considered significant and marked with an asterix (*). H, Hemisphere; N, number of voxels; ME, main effect. ††Reported is the closest gray matter area identified manually. d,r, effect sizes.