Figure 7.

Variability of gating properties of tityustoxin-sensitive channels in dissociated hippocampal neurons. A, Summary of use-dependent properties of neurons subjected to repetitive depolarizations at the indicated frequencies. Cells exhibit a range of use-dependent activation and/or inactivation. B, Sample traces of 10 Hz recordings of tityustoxin-sensitive currents from hippocampal neurons, illustrating extreme cases of either use-dependent activation (top) or inactivation (bottom). C, Sample traces from longer pulse durations, illustrating the cell-to-cell variability of inactivation, and the emergence of use-dependent potentiation in the sustained current component of some cells with pronounced inactivation (middle and right).