Figure 6.

GABA_ARs composed only of β3 and γ2 subunits are DA-gated ion channels. A, Typical traces demonstrating currents evoked by DA (filled bars), GABA or Pb (unfilled bars) applied to cells transfected with ^Zβ3γ2 (top), ^Zβ3 (middle), or γ2 (bottom). B, Mean ± SEM for current amplitudes elicited by DA compared with 0.1 mm Pb in individual cells. C, Concentration–response curves (mean ± SEM) for DA activation in cells transfected with ^Zβ3γ2, wild-type β3γ2, or α1^Zβ3γ2. Responses are normalized to current amplitudes from 10 mm DA in individual cells.