Figure 7.

Effects of GABA_A antagonists on DA-gated GABA_ARs. A–C, For α1^Zβ3γ2, traces show typical effects of DA (1 mm, unfilled bars) or antagonist (10 μm, filled bars) applied alone (left) or in the middle of a DA pulse (1 mm, right). D, Comparative analysis (mean ± SEM) of antagonists acting on α1^Zβ3γ2 alone or in combination with DA. All comparisons are made to 1 mm DA-evoked amplitudes in individual cells (normalized to −1, dotted line). Concentrations are the same as A–C. Washoff represents removal of antagonist only. E–G, Same as A–C, but for ^Zβ3γ2 receptors instead of α1^Zβ3γ2. H, Analysis as done in D, except with ^Zβ3γ2. I, Example of statistical comparisons and symbols used in Table 1 for a single ANOVA of a hypothetical drug. All comparisons for Figure 7 are shown in Table 1.