Table 1.
α1Zβ3γ2 | Drug alone | Drug + DA | Wash | Zβ3γ2 | Drug alone | Drug + DA | Wash |
---|---|---|---|---|---|---|---|
BIC | ****/†††† | §§§§/†††† | Not significant | BIC | ****/†††† | §§§§/†† | Not significant |
GBZ | ****/†††† | §§§§/†††† | Not significant | GBZ | ****/†††† | §§§§/†††† | Not significant |
PTX | ****/†††† | Not significant/†††† | ††† | PTX | **/†††† | Not significant/†††† | †††† |
aSummary of statistical significance for GABAA antagonists modulating α1Zβ3γ2 (Fig. 7D) or Zβ3γ2 (Fig. 7H) receptors. Columns represent drug perfused alone (black bars from figure), drug applied with DA (hatched bars), or drug washoff with DA still present (white bars). Compounds were segregated by subtype and separately analyzed in one-way ANOVAs. Symbols show p values calculated within each ANOVA from Bonferroni's tests comparing data to baseline (*), DA (†), or drug alone (§; Fig. 7I). The correspondence between number of symbols and significance is as follows: 1, p ≤ 0.05; 2, p ≤ 0.01; 3, p ≤ 0.001; 4, p ≤ 0.0001.