Figure 2.

Effects of D2-receptor blockade on reward signals. A, Schematic of the searchlight decoding approach. Activity patterns were extracted for all four cue-outcome pairs from each searchlight. An SVC model was trained to discriminate reward from no reward on set I only or set II only. This yielded predictions that were then tested on the other set (testing on set II after training on set I and vice versa) to obtain decoding accuracy, which was assigned to the center voxel. This procedure was repeated for every searchlight (center voxel) in the entire brain, resulting in a 3D map of decoding accuracy. B, Cluster in the medial OFC with significantly (p_FWE-corr< 0.05) higher decoding accuracy in the amisulpride (Ami) than placebo (Pla) group. C, For illustration purposes, bar plots depict averaged decoding accuracy from individual peak searchlights in the OFC cluster for both groups. Error bars depict 95% CI.