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. 2015 Feb 18;35(7):3190–3200. doi: 10.1523/JNEUROSCI.4864-13.2015

Figure 5.

Figure 5.

ERK activity and protein levels are altered in the 16p11.2del cortex. a, IHC of phospho-ERK1/2 from E14.5 WT and 16p11.2del forebrains. ERK activity primarily localizes to ventricular zones and is increased in 16p11.2del mice. b, Western blot analysis of cortical lysates isolated from E14.5 embryos of WT and 16p11.2del (Del) littermates. c, 16p11.2del mice have decreased levels of ERK1 (***p < 0.001) and combined ERK1/2 (***p = 0.0007), but normal ERK2 levels (p = 0.43) due to loss of one ERK1 allele. d, 16p11.2del mice have increased levels of phosphorylated ERK1 (**p = 0.0051), ERK2 (*p = 0.0255), and combined phospho-ERK1/2 (*p = 0.02, nwt = 17 and ndel = 16). *p < 0.05. **p < 0.01. ***p < 0.001.