Figure 10.

Preventing astrocyte reactivity modulates HD pathology. Immunostaining of the striatal neuronal marker DARPP32 and histochemistry of COX in mice injected in the left striatum with lenti-Htt82Q plus lenti-GFP and in the right striatum with lenti-Htt82Q plus lenti-SOCS3 plus lenti-GFP. mHtt aggregates are detected by immunostaining with EM48 in the same mice, and they form nuclear inclusions (see enlargement). Quantification of the lesion size and the number of EM48⁺ aggregates. SOCS3 increases the number of EM48⁺ aggregates. n = 11. *p < 0.05. Scale bar, 500 μm.