Figure 3.

The JAK/STAT3 pathway is activated in reactive astrocytes in 3xTg-AD mice. A, B, Images of brain sections from the subiculum of 12-month-old 3xTg-AD mice. STAT3 (green) accumulates in the nucleus of reactive astrocytes labeled with GFAP (A, red) or vimentin (B, red), especially around amyloid plaques (arrowheads). C, The number of nSTAT3⁺/GFAP⁺ cells is significantly higher in 3xTg-AD mice than in age-matched WT controls. n = 3–5 per group. ***p < 0.001. Scale bars: 20 μm; enlargements, 5 μm.