Figure 5.

The JAK/STAT3 pathway is activated in reactive astrocytes in the primate model of HD. A, Images of brain sections from macaques injected with lenti-Htt82Q in the putamen showing triple staining for STAT3 (green), GFAP (red), and EM48 (magenta). Seventeen months after infection with lenti-Htt82Q in the putamen, EM48⁺ aggregates of mHtt are observed, as well as prominent astrocyte reactivity. The immunoreactivity for STAT3 is much stronger in GFAP⁺ reactive astrocytes than in resting astrocytes found outside the injected area in the same animal. Images are representative of all three macaques. Scale bars: 40 μm; enlargement, 10 μm.