Figure 6.

The NF-κB pathway is not activated in 3xTg-AD mice and the lentiviral-based model of HD. Western blot for IκBα and GAPDH in 3xTg-AD mice (3xTg) or their age-matched WT controls (A) or mice injected in the left striatum with lenti-Htt18Q (18Q) and in the right striatum with lenti-Htt82Q (82Q; B). IκBα expression is similar between 3xTg-AD and WT mice and between the left and right striatum of mice injected with lenti-Htt. The abundance of IκBα is lower in HeLa cells treated with TNFα (positive control, +) than in untreated cells (negative control, −). n = 4–6 mice per group.