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. 2015 Feb 11;35(6):2817–2829. doi: 10.1523/JNEUROSCI.3516-14.2015

Figure 9.

Figure 9.

Preventing astrocyte reactivity reduces microglial activation. A, Immunofluorescent staining of GFP (green) and IBA1 (red) in mice injected in the left striatum with lenti-Htt82Q plus lenti-GFP and the right striatum with lenti-Htt82Q plus lenti-SOCS3 plus lenti-GFP. B, Quantification shows that the IBA1+ area is significantly smaller in the striatum injected with lenti-SOCS3 than in the control striatum. C–E, qRT-PCR analysis on mice injected in the striatum with lenti-Htt18Q plus lenti-GFP, lenti-Htt18Q plus lenti-SOCS3 plus lenti-GFP, lenti-Htt82Q plus lenti-GFP, or lenti-Htt82Q plus lenti-SOCS3 plus lenti-GFP (same total virus load). The expression of aif1 (iba1; C), itgam (CD11b; D), and ccl2 (E) is induced by lenti-Htt82Q and is reduced by SOCS3. n = 4–11 per group. *p < 0.05, **p < 0.01, ***p < 0.001, #p < 0.05 versus Htt18Q plus GFP and Htt18Q plus SOCS3. Scale bar, 20 μm.