Figure 6.

aOn-Off DSGCs show laminar-specific alterations in their dendritic structure. A–F, Same as in Figure 5 but for aOn-Off DSGCs labeled in Hoxd10-GFP mice. G–I, No significant changes were noted for soma size (G), dendritic length (H), and dendritic field area (I) of aOn-Off DSGCs in control (white bars) and IOP-elevated retinas (black bars). J–M, RGCs had a larger number of total dendritic branches (J) in IOP-elevated retina, caused by an increase in the length of the dendrites present in the On sublamina (K, L) and a reduction of Off-sublamina dendrites (K, M). N–P, Sholl analysis revealing the increased branching of On-sublamina dendrites (O, asterisk) and reduction of Off-sublamina ones (P, asterisk). For G–P, t test *p < 0.05 and **p < 0.01; error bars represent ±SEM. For C–F, the soma, axon (arrow), and On dendrites are shown in red, and Off-sublamina dendrites are shown in black. Scale bar: A, 50 μm.