Figure 3.

Inhibiting NMDAR activity prevents the impairment caused by rapamycin. Rats were trained in an auditory fear-conditioning task and received an infusion of ifenprodil alone (n = 8), vehicle (VH; n = 11), rapamycin alone (n = 12), or a mixture of rapamycin and ifenprodil (Cocktail; n = 8) before Test 1. Rats infused with the cocktail were not impaired in performance, as opposed to rats infused with rapamycin only. Rats showed intact fear expression when tested at Test 2. Data are expressed as the mean ± SEM percentage of time spent freezing in response to the tone. *p < 0.05.