Figure 4.
Inhibiting endocytosis of GluA2-containing AMPARs prevents the impairment caused by rapamycin. Rats were trained in an auditory fear-conditioning task and received an infusion of GluA23Y and rapamycin (GluA23Y/Rap; n = 8), scrambled-GluA23Y and rapamycin (Scr/Rap; n = 8), GluA23Y and DMSO (GluA23Y/DMSO; n = 8), or vehicle (Scr/DMSO; n = 12). Rats infused with both GluA23Y and rapamycin were not impaired in performance, as opposed to rats infused with rapamycin only. Rats showed intact fear expression when tested at Test 2. Data are expressed as the mean ± SEM percentage of time spent freezing in response to the tone. *p < 0.05.