Figure 6.
Infusion of rapamycin does not affect GluA2 levels at the PSD or at extrasynaptic sites. Rats were trained in an auditory fear-conditioning task and received an infusion of GluA23Y and rapamycin (GluA23Y/Rap; n = 12), scrambled-GluA23Y and rapamycin (Scr/Rap; n = 17), GluA23Y and DMSO (GluA23Y/DMSO; n = 12), or vehicle (Scr/DMSO; n = 13). A, C, Results show no significant correlation between the percentage of time spent freezing in the memory retrieval test and levels of GluA2 at the PSD (A) or extrasynaptic sites (C). B, D, GluA2 levels were equivalent in all groups at the PSD (B) and at extrasynaptic sites (D). Levels of GluA2 are expressed as relative percentage values of the vehicle group ± SEM.