Table VII.
Univariate and multivariate analyses of NUF2 and survival in GEO datasets.
| Dataset | Overall survival
|
Progression-free survival
|
||
|---|---|---|---|---|
| HR (95% CI) | Adjusted HR (95% CI) | HR (95% CI) | Adjusted HR (95% CI) | |
| GSE1456 | ||||
| X1 | Reference | Reference | Reference | Reference |
| X2 | 3.94 (0.82-18.95) | 3.66 (0.75-17.75) | 2.19 (0.55-8.74) | 1.99 (0.49-8.05) |
| X3 | 6.18 (1.37-27.90)a | 4.6 (0.91-23.28) | 5.7 (1.64-19.83)b | 3.94 (1.00-15.45)a |
| X4 | 6.69 (1.50-29.91)a | 5.11 (1.03-25.24)a | 5.21 (1.48-18.29)b | 3.76 (0.97-14.57) |
| GSE22220 | ||||
| X1 | N/A | N/A | Reference | Reference |
| X2 | N/A | N/A | 2.05 (0.95-4.43) | 1.69 (0.77-3.69) |
| X3 | N/A | N/A | 2.31 (1.07-4.96)a | 1.79 (0.82-3.92) |
| X4 | N/A | N/A | 3.34 (1.60-6.95)b | 2.30 (1.05-5.02)a |
| NKI dataset | ||||
| X1 | Reference | Reference | Reference | Reference |
| X2 | 2.39 (1.04-5.51)a | 2.01 (0.87-4.68) | 1.35 (0.72-2.54) | 1.29 (0.68-2.46) |
| X3 | 3.97 (1.80-8.77)b | 2.88 (1.28-6.48)a | 2.39 (1.33-4.30)b | 1.97 (1.07-3.61)a |
| X4 | 4.48 (2.03-9.89)c | 2.63 (1.13-6.12)a | 2.31 (1.27-4.21)b | 1.84 (0.96-3.52) |
| GSE4299 | ||||
| X1 | N/A | N/A | Reference | Reference |
| X2 | N/A | N/A | 1.95 (0.99-3.85) | 1.93 (0.97-3.81) |
| X3 | N/A | N/A | 2.16 (1.09-4.27)a | 2.13 (1.07-4.24)a |
| X4 | N/A | N/A | 2.11 (1.07-4.17)a | 2.09 (1.04-4.19)a |
| GSE20685 | ||||
| X1 | Reference | Reference | Reference | Reference |
| X2 | 1.11 (0.57-2.14) | 1.1 (0.57-2.14) | 1.17 (0.67-2.05) | 1.16 (0.66-2.03) |
| X3 | 1.58 (0.85-2.95) | 1.58 (0.85-2.95) | 1.12 (0.64-1.98) | 1.13 (0.64-2.00) |
| X4 | 1.59 (0.85-2.96) | 1.58 (0.84-2.97) | 1.46 (0.84-2.52) | 1.42 (0.82-2.48) |
| GEO pooled | ||||
| X1 | Reference | Reference | Reference | Reference |
| X2 | 2.69 (1.29-5.60)b | 2.18 (1.04-4.57)a | 1.67 (1.05-2.65)a | 1.5 (0.95-2.39) |
| X3 | 4.43 (2.20-8.91)c | 3 (1.46-6.15)b | 2.72 (1.77-4.19)c | 2.13 (1.36-3.32)b |
| X4 | 4.94 (2.46-9.92)c | 2.87 (1.38-5.94)b | 2.98 (1.94-4.59)c | 2.1 (1.33-3.32)b |
| GEO pooled ER(+) | ||||
| X1 | Reference | Reference | Reference | Reference |
| X2 | 3.84 (1.41-10.48)b | 3.23 (1.18-8.88)a | 1.57 (0.79-3.13) | 1.39 (0.70-2.79) |
| X3 | 5.48 (2.08-14.49)b | 3.93 (1.46-10.61)b | 3.03 (1.62-5.69)b | 2.32 (1.22-4.44)a |
| X4 | 5.60 (2.06-15.23)b | 3.74 (1.34-10.46)a | 2.83 (1.45-5.52)b | 2.09 (1.04-4.16)a |
| GEO pooled ER(−) | ||||
| X1 | Reference | Reference | Reference | Reference |
| X2 | 1.40 (0.46-4.20) | 1.19 (0.39-3.61) | 1.28 (0.46-3.62) | 1.09 (0.38-3.11) |
| X3 | 2.96 (1.07-8.20)a | 1.88 (0.65-5.45) | 2.60 (1.01-6.72)a | 1.58 (0.58-4.34) |
| X4 | 3.23 (1.22-8.54)a | 1.96 (0.70-5.52) | 2.44 (0.97-6.10) | 1.46 (0.54-3.91) |
For multivariate analysis, HR was adjusted by ER status and Elston grade in GSE1456. In GSE22220, HR was adjusted by age and Elston grade. In NKI and GSE4299, HR was adjusted by age, Elston grade, and ER status. For GSE20685, HR was adjusted by age. HR was adjusted by ER status and Elston grade in the pooled analysis. For GEO pooled ER(+) and GEO pooled ER(−), HR was adjusted by Elston grade.
a
P<0.05,
b
P<0.01 and
c
P<0.001 vs. the X1 group. HR, hazard ratio; ER, estrogen receptor; GEO, gene expression omnibus; CI, confidence interval.