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. 2019 May 23;44(2):582–592. doi: 10.3892/ijmm.2019.4207

Figure 4.

Figure 4

ZOL inhibits RANKL-induced osteoclast-specific gene expression. RAW264.7 cells were cultured with or without 100 ng/ml RANKL and treated with 0, 0.1, 1 or 5 µM ZOL. (A-F) The expression of osteoclast-specific genes (CTR, DC-STAMP, RANK, TRAP, c-Fos and NFATc1) was detected by RT-qPCR. Results were normalized to the expression of the GAPDH gene. ##P<0.01 vs. the vehicle group; *P<0.05, **P<0.01 vs. the RANKL-only group. CTR, calcitonin receptor; TRAP, tartrate-resistant acid phosphatase; DC-STAMP, dendritic cell-specific transmembrane protein; ZOL, zoledronic acid; RANKL, receptor activator of nuclear-κB ligand; NFATc1, nuclear factor of activated T cells 1.