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. 2019 Apr 22;151(7):944–953. doi: 10.1085/jgp.201812224

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© 2019 Lee et al.

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Figure 3. — The prolonged desensitization exhibited by the ASIC2a mutants can be partially reversed after a long resting period. (A) Currents elicited in HEK293T cells expressing Mut2 (upper) and Mut3 (lower) after two successive applications of pH 4.0 with variable interstimulus intervals: 2 min (black), 5 min (red), or 10 min (blue). Acidic stimuli were delivered by switching the bath solution from pH 7.4 to pH 4.0. (B) Peak current densities elicited by the second pH-4.0 treatment normalized to those elicited by the first pH-4.0 treatment. n = 6–8 for each group. *, P < 0.05; ***, P < 0.001, one-way ANOVA followed by Dunnett’s multiple comparisons corrections with 2-min interval.