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. 2019 Apr 22;151(7):944–953. doi: 10.1085/jgp.201812224

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© 2019 Lee et al.

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Figure 4. — T25, T39, and I40 at the N terminus of ASIC2a are required for the rapid resensitization of the ion channel following the response to extracellular protons. (A) Alignment of ASIC2a (1–68) and ASIC2b (1–112) amino acid sequences. (B, C, E, F, and H) Schematic showing the structure of the indicated mutant and its current responses elicited by three successive applications of pH 4.0 delivered at 2-min intervals. Acidic stimuli were delivered by switching the bath solution from pH 7.4 to pH 4.0. (D, G, and I) Peak current densities normalized to those elicited by the first application of pH 4.0. n = 5–9 for each group. ***, P < 0.001; ****, P < 0.0001, two-way ANOVA followed by Tukey’s multiple comparisons test.