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. 2019 Apr 22;151(7):944–953. doi: 10.1085/jgp.201812224

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© 2019 Lee et al.

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Figure 5. — The desensitization and resensitization of ASIC1a and ASIC2a are mediated by distinct amino acids in the N termini. (A) Alignment of ASIC1a (1–67), ASIC2a (1–66), and ASIC1b (1–112) amino acid sequences. (B) Currents elicited by three successive applications of pH 4.0 delivered at 2-min intervals in cells transfected with the indicated ASIC1a mutant. Acidic stimuli were delivered by switching the bath solution from pH 7.4 to pH 4.0. (C) Peak current densities normalized to those evoked by the first stimulus. n = 5 for each group. *, P < 0.05, two-way ANOVA followed by Tukey’s multiple comparisons test.