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. 2019 Apr 22;151(7):944–953. doi: 10.1085/jgp.201812224

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© 2019 Lee et al.

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Figure 6. — The N terminus of ASIC2a is involved in the rapid resensitization of heteromeric ASIC channels following the response to extracellular protons. (A, C, and F) Currents elicited by three successive applications of pH 4.0 in HEK293T cells transiently transfected with the indicated ASIC cDNAs. Acidic stimuli were delivered by switching the bath solution from pH 7.4 to pH 4.0 at 2-min intervals. The dashed line indicates the zero-current level. (B, D, and G) Peak current densities normalized to those elicited by the initial acidic stimulus. n = 5–8 for each group. ***, P < 0.001; ****, P < 0.0001, two-way ANOVA followed by Tukey’s multiple comparisons corrections. (E) Peak current densities elicited by the initial acidic stimulus.