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. 2019 Jun 12;44(2):683–693. doi: 10.3892/ijmm.2019.4241

Figure 3.

Figure 3

miR-145 is required for the celecoxib-mediated inhibition of EMT. (A) Quantified results from reverse transcription-quantitative polymerase chain reaction analysis following the transfection of 5637 and T24 cells with miR-145 mimics and inhibitors. (B) Celecoxib inhibited the invasion of 5637 cells, while miR-145 inhibitor treatment rescued the effect. (C) Alteration of the expression levels of the EMT-associated markers E-cadherin and Vimentin, caused by celecoxib (60 µM) treatment, were rescued by transfection with the miR-145 inhibitor. (D) Statistical analysis of (C). **P<0.05 vs. miR-NC or the celecoxib (60 µM) + miR-145 inhibitor group. miR, microRNA; EMT, epithelial-to-mesenchymal transition; NC, negative control; DMSO, dimethyl sulfoxide.