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. 2019 Jun 20;15(6):e1007833. doi: 10.1371/journal.ppat.1007833

Fig 4. Early serum cytokine responses occur in SC-infected rats compared to a late cytokine/chemokine storm in the brain of AERO-infected rats.

Fig 4

Cytokines were assessed by a 22-plex Luminex kit. (A) Select serum cytokines. (B) Select cytokines in homogenized brain tissue. CTL represents mock-infected rats. For statistical analysis, 2-way ANOVA with multiple comparisons was performed (see Methods section). The # in the bottom right corner indicates significance by 2-way ANOVA (N.S., not significant; #, P < 0.05; ##, P < 0.01; ###, P < 0.001; ####, P < 0.0001); asterisks above symbols indicate significance of individual time points compared to uninfected (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001). Asterisk above a bar indicates significance over the encompassed data points.