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. 2019 Jun 20;15(6):e1007833. doi: 10.1371/journal.ppat.1007833

Fig 11. Prevention of neutrophil migration into the brain using a CXCR2 antagonist.

Fig 11

RVFV-infected rats were treated with SB-265610 on 0 dpi, 3 dpi, or a vehicle control. (A) Survival curve. Neither 3 dpi nor 0 dpi were significantly different from vehicle control rats using Log-rank Mantel-Cox test. (B) Number of neutrophils in rat brains at time of necropsy as measured by flow cytometry (n = 3 rats/tx group; n = 2 for no tx group). One-way ANOVA with multiple comparisons was used to determine statistical significance. Representative flow plots of neutrophils (RP-1+, CD11b+, CD45+) for (C) no treatment (no Tx) (D) 0 dpi, and (E) 3 dpi treatment groups. Color gradient in B-D indicates RVFV antigen expression, with red indicating the brightest expression and blue the lowest.