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. 2019 May 9;216(7):1561–1581. doi: 10.1084/jem.20181994

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© 2019 Durand et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 3. — Tonsil CD14⁺ cells do not contain a population of DC. Purified tonsil HLA-DR⁺CD11c⁺CD14⁻ cells and HLA-DR⁺CD11c⁺CD14⁺ cells were analyzed by single-cell RNA-seq using a Drop-seq approach. Combined single-cell transcriptomes were analyzed. (A and B) t-SNE representation of cell clusters identified using unsupervised clustering. Each dot represents an individual cell. (A) Colors represent sample origin. (B) Colors represent identified clusters. Clusters are manually ordered. (C) Heatmap of scaled expression (log values of UMI) for the top 25 differentially expressed genes of each cluster (based on log fold change). (D) Signature scores (arbitrary units) in individual cells for indicated gene signatures.