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. 2019 May 16;216(7):1542–1560. doi: 10.1084/jem.20182386

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© 2019 Dodiya et al.

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Figure 5. — FMT reverts ABX-associated changes in the gut microbiome (n = 9/group). (A) Cecum weights from vehicle- or FMT-treated ABX-treated male mice. FMT introduced into ABX-treated APPPS1-21 male mice lead to reduced cecum weight (unpaired Student’s t test: t_[16] = 4.372, P = 0.0005). (B) PCoA plot generated by using unweighted versions of the UniFrac distance metric. The two components explained 44.98% of the variance. FMT-treated ABX-treated male mice showed no clear separation compared with the donor fecal microbiome while vehicle-treated ABX-treated male mice showed a clear separation compared with the other two groups. The α diversity was measured by using Pielou’s evenness (Pielou_E; C) and Faith's phylogenetic diversity (Faith_pd; D) indices. FMT treatment restored the microbiome diversity as measured by both Faith’s phylogenetic diversity (one-way ANOVA: F_[2,16] = 32.91, P < 0.0001) and Pielou’s evenness (one-way ANOVA: F_[2,16] = 18.7, P < 0.0001). Data are mean ± SEM. *, P < 0.05; ***, P < 0.001; ****, P < 0.0001. n = 9/group. PCA1, principal coordinate 1; PCA2, principal coordinate 2.