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. 2019 May 21;218(7):2150–2168. doi: 10.1083/jcb.201805044

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© 2019 David et al.

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Figure 7. — Model for k-fiber assembly. Once “pioneer” MTs generated at the spindle poles (SPs) attach to KTs, they become templates for Augmin-mediated amplification. Augmin accumulates on long-lived MT lattices and generates an increasing fraction of spindle MTs (a). This leads to a measurable KT-directed bias in MT plus end growth (b). Together with stabilization and poleward transport of MTs (c), this amounts to a strong positive feedback loop conducive to rapid k-fiber assembly.