Table 4.
Adverse reactions after vaccination by study groupse.
| Type and Grade | CS1 | CS2 | CS3 | LPS | Total | P valuef |
|---|---|---|---|---|---|---|
| Overall | 61 (17.84) | 46 (13.45) | 51 (14.96) | 27 (15.88) | 185 (15.48) | 0.4569 |
| Grade 3 | 3 (0.88) | 5 (1.46) | 1 (0.29) | 1 (0.59) | 10 (0.84) | 0.4507 |
| Solicited | 59 (17.25) | 44 (12.87) | 51 (14.96) | 25 (14.71) | 179 (14.98) | 0.4596 |
| Local | ||||||
| Redness | 0 (0.00) | 1 (0.29) | 2 (0.59) | 0 (0.00) | 3 (0.25) | 0.5086 |
| Pain | 3 (0.88) | 1 (0.29) | 0 (0.00) | 2 (1.18) | 6 (0.50) | 0.1534 |
| Rash (injection site) | 1 (0.29) | 0 (0.00) | 0 (0.00) | 1 (0.59) | 2 (0.17) | 0.3456 |
| Swelling | 0 (0.00) | 1 (0.29) | 0 (0.00) | 0 (0.00) | 1 (0.08) | 1.0000 |
| Pruritus | 2 (0.58) | 1 (0.29) | 0 (0.00) | 1 (0.59) | 4 (0.33) | 0.6385 |
| Systemic | ||||||
| Fever | 50 (14.62) | 41 (11.99) | 49 (14.37) | 20 (11.76) | 160 (13.39) | 0.6508 |
| Cough | 4 (1.17) | 1 (0.29) | 0 (0.00) | 3 (1.76) | 8 (0.67) | 0.0389 |
| Nausea/Vomiting | 0 (0.00) | 0 (0.00) | 1 (0.29) | 0 (0.00) | 1 (0.08) | 0.4276 |
| Malaise | 1 (0.29) | 1 (0.29) | 0 (0.00) | 0 (0.00) | 2 (0.17) | 1.0000 |
| Allergy | 2 (0.58) | 1 (0.29) | 0 (0.00) | 0 (0.00) | 3 (0.25) | 0.8594 |
| Unsolicited | 2 (0.58) | 2 (0.58) | 0 (0.00) | 2 (1.18) | 6 (0.50) | 0.2877 |
eThe adverse reactions was presented as No. (%).
fThe P values were calculated for comparisons of the four groups by Pearson’s chi-square or Fisher’ exact test.