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. 2019 Apr 22;15(5):1139–1144. doi: 10.1080/21645515.2019.1578591

Table 3.

Immunogenicity against different mumps genotypes and ELISA antibodies.

Mumps NT against JVC-001 (n = 49) MR+Mumps (n = 50)
Genotype A    
Seroconversion rate 41/48 (85.4%, [72.2–93.9%]) 28/50 (56.0%, [41.3–70.0%])
GMT at Day 42 19.9, [95% CI: 13.2–29.9] 5.8 [95% CI: 4.0–8.4]
Genotype B    
Seroconversion rate 41/48 (85.4%, [72.2–93.9%]) 33/50 (66.0%, [51.2–78.8%])
GMT at Day 42 15.8, [95% CI: 10.9–22.8] 6.8, [95% CI: 4.8–9.6]
Genotype G    
Seroconversion rate 37/48 (77.1%, [62.7–88.0%]) 32/49 (65.3%, [50.4–78.3%])
GMT at Day 42 12.5, [95% CI: 8.6–18.3] 7.1, [95% CI: 5.0–10.1]
Genotype D    
Seroconversion rate 39/43 (90.7%, [77.9−97.4%]) 46/48 (95.8%, [85.8–99.5%])
Seroresponse rate 38/43 (88.4%, [74.9–96.1%]) 42/48 (87.5%, [74.8–95.3%])
GMT at Day 42
32.1, [95% CI: 19.6–52.4]
31.4, [95% CI:19.6–50.5]
Mumps ELISA
JVC-001 (n = 49)
MR+Mumps (n = 50)
Seroconversion rate 45/48 (93.8%, [82.8–98.7%]) 46/49 (93.9%, [83.1–98.7%])
GMT at Day 42 1745.0, [95% CI: 1250.2–2435.5] 1400.4, [95% CI: 964.6–2033.0]

Note: See immunological assessment section for the definition of seroconversion/seroresponse rate. Population parameters of each seroconversion/seroresponse rate were calculated based on each definition with each cut-off value in pre-immunization. Subjects whose assay data was failed to obtain were also eliminated from the calculation.