Table 3.
Immunogenicity against different mumps genotypes and ELISA antibodies.
| Mumps NT against | JVC-001 (n = 49) | MR+Mumps (n = 50) |
|---|---|---|
| Genotype A | ||
| Seroconversion rate | 41/48 (85.4%, [72.2–93.9%]) | 28/50 (56.0%, [41.3–70.0%]) |
| GMT at Day 42 | 19.9, [95% CI: 13.2–29.9] | 5.8 [95% CI: 4.0–8.4] |
| Genotype B | ||
| Seroconversion rate | 41/48 (85.4%, [72.2–93.9%]) | 33/50 (66.0%, [51.2–78.8%]) |
| GMT at Day 42 | 15.8, [95% CI: 10.9–22.8] | 6.8, [95% CI: 4.8–9.6] |
| Genotype G | ||
| Seroconversion rate | 37/48 (77.1%, [62.7–88.0%]) | 32/49 (65.3%, [50.4–78.3%]) |
| GMT at Day 42 | 12.5, [95% CI: 8.6–18.3] | 7.1, [95% CI: 5.0–10.1] |
| Genotype D | ||
| Seroconversion rate | 39/43 (90.7%, [77.9−97.4%]) | 46/48 (95.8%, [85.8–99.5%]) |
| Seroresponse rate | 38/43 (88.4%, [74.9–96.1%]) | 42/48 (87.5%, [74.8–95.3%]) |
| GMT at Day 42 |
32.1, [95% CI: 19.6–52.4] |
31.4, [95% CI:19.6–50.5] |
| Mumps ELISA |
JVC-001 (n = 49) |
MR+Mumps (n = 50) |
| Seroconversion rate | 45/48 (93.8%, [82.8–98.7%]) | 46/49 (93.9%, [83.1–98.7%]) |
| GMT at Day 42 | 1745.0, [95% CI: 1250.2–2435.5] | 1400.4, [95% CI: 964.6–2033.0] |
Note: See immunological assessment section for the definition of seroconversion/seroresponse rate. Population parameters of each seroconversion/seroresponse rate were calculated based on each definition with each cut-off value in pre-immunization. Subjects whose assay data was failed to obtain were also eliminated from the calculation.