Comparison 2. Treatment of upper gastrointestinal bleeding.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All cause mortality to near term age or discharge	2	131	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.26, 1.51]
1.1 H2RA versus no treatment	2	131	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.26, 1.51]
2 Duration of upper gastrointestinal bleeding in infants with upper gastrointestinal bleeding (days)	2	104	Mean Difference (IV, Fixed, 95% CI)	‐1.06 [‐1.28, ‐0.84]
2.1 PPIs versus no treatment	1	66	Mean Difference (IV, Fixed, 95% CI)	‐1.06 [‐1.28, ‐0.84]
2.2 H2RA versus no treatment	1	38	Mean Difference (IV, Fixed, 95% CI)	‐9.5 [‐19.55, 0.55]
3 Continued upper gastrointestinal bleeding in infants with upper gastrointestinal bleeding at latest time reported	6	451	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.26, 0.49]
3.1 PPIs versus no treatment	3	263	Risk Ratio (M‐H, Fixed, 95% CI)	0.39 [0.27, 0.57]
3.2 H2RA versus no treatment	3	188	Risk Ratio (M‐H, Fixed, 95% CI)	0.30 [0.17, 0.54]
4 Anaemia requiring blood transfusion	1	38	Risk Ratio (M‐H, Fixed, 95% CI)	0.6 [0.11, 3.19]
4.1 H2RA versus no treatment	1	38	Risk Ratio (M‐H, Fixed, 95% CI)	0.6 [0.11, 3.19]
5 Serious adverse reactions	4	226	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.1 H2RA versus no treatment	4	226	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]