Lu 1995.

Methods	Randomised controlled trial in China January 1990 to October 1992.
Participants	Inclusion criteria: sick term and preterm newborns at high risk of gastric bleeding. Exclusion criteria: none reported.
Interventions	Intervention (n = 56): cimetidine 5 mg/kg/dose intravenously in 10% glucose twice daily for 3 to 5 days. Control (n = 62): no treatment. All infants given vitamin K 5 mg/day [route not reported] for 3 days.
Outcomes	Acute gastric mucosa lesion (diagnosed by tarry stool or coffee‐ground vomit); bleeding amount and time ‒ hematemesis; melena or test positive for blood (clinical acute gastric lesion).
Notes	Authors did not believe there were any adverse reactions attributable to the intervention. It was unclear how bleeding time was determined, given that these infants did not have bleeding initially. As a result, it could not be included in the 'duration of upper gastrointestinal bleeding in infants with upper gastrointestinal bleeding (days)' outcome.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Reported: "randomly assigned".
Allocation concealment (selection bias)	Unclear risk	Method not reported.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported.
Incomplete outcome data (attrition bias) All outcomes	Low risk	None reported.
Selective reporting (reporting bias)	Unclear risk	No protocol available.
Other bias	Unclear risk	Similar baseline characteristics between groups.