Table 1.
Tumor-derived exosomal lncRNAs in human cancer.
| Origin of tumor | lncRNA | Regulation | Biological function | Refs. |
|---|---|---|---|---|
| Cervical cancer | MALAT1 | up | For the detection and diagnosis in the clinic | 29,94 |
| HOTAIR | up | 30,94 | ||
| MEG3 | up | 31,94 | ||
| Colorectal cancer (serum) | CRNDE-h | up | Serve as a prognostic predictor in the clinic | 90 |
| Glioma cancer | lincPOU3F3 | up | Promote angiogenesis | 73 |
| Gastric cancer | ZFAS1 | up | Enhance cell cycle progression, proliferation and migration | 82 |
| Breast cancer, bladder cancer | UCA1 | up | Enhance drug resistance, facilitate tumor growth, for the diagnostic biomarker | 70,99 |
| HCC | lincVLDLR | up | Increase cancer cell drug resistance | 101 |
| lincROR | up | Enhance chemoresistance, promote cell survival | 102,103 | |
| TUC339 | up | Promote cancer cell growth and adhesion | 69 | |
| Pancreatic cancer | ENST00000560647 | up | Increase dendritic cell immune escape | 84 |
| HCV-induced HCC (serum) | HEIH | up | For the detection and diagnosis in the clinic | 93 |
| Non-small lung cancer | MALAT-1 | up | Promote tumor growth and migration, for the diagnostic biomarker | 65 |
| Colorectal cancer (serum) | BCAR4 | up | For the detection and diagnosis in the clinic | 14 |
| Renal cell carcinoma | ARSR | up | Promote agents resistance | 104 |
| Bladder cancer | HOTAIR | up | Increase cancer cells migration and invasion | 98 |
| Colon cancer(CRC) | ZFAS1 | up | For the detection and diagnosis in the clinic | 91 |
| SNHGs | up | For the detection and diagnosis in the clinic | ||
| Epithelial ovarian cancer | ENST00000444164 | up | Reverse tumor-related immune response | 86 |
| ENST0000043768 | up | Reverse tumor-related immune response | ||
| Lung cancer | HMlincRNA1636+ | up | 9.1% of lncRNAs (2775 out of 30586) were differentially expressed upon treatment with lung tumor cell exosome |
66 |
| NR_046464 | up | |||
| NR_052024 | up | |||
| ENST00000420309 | up | |||
| NR_046466 | up | |||
| NR_045370 | up | |||
| NR_024596 | up | |||
| ENST00000520714 | up | |||
| uc010hbj.3 | up | |||
| ENST00000440436 | up | |||
| ENST00000428453 | down | |||
| ENST00000426501 | down | |||
| TCONS_00006633 | down | |||
| ENST00000440714 | down | |||
| uc010ciy.1 | down | |||
| NR_048550 | down | |||
| uc011aef.2 | down | |||
| uc002rwa.2 | down | |||
| ENST00000488190 | down | |||
| Cb112975 | down | |||
| CD90+ liver cancer | H19 | up | Promote angiogenesis | 76 |
| Prostate cancer | P21 | up | For the detection and diagnosis in the clinic | 97 |