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Possible mechanisms by which pemetrexed and fingolimod/FTY720 interact to kill NSCLC cells. A schematic representing the signaling pathways and biology being examined in this manuscript. This includes inhibition of upstream signaling at the level of receptors; the activation of a DNA damage and ATM-AMPK response; and the regulatory pathways influencing autophagosome formation, autolysosome formation and the induction of tumor cell death.
