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. 2018 Nov 21;20(5):617–632. doi: 10.1080/15384047.2018.1539290

Figure 2.

Figure 2.

MDM2/MDMX inhibitor in combination with DOX inhibit TNBC cell invasion. Cells were treated with the indicated agents for 24 h, and cell invasion was detected using transwell assay. The concentrations of each agent were used as follow: DOX 0.29 µM in MDA-MB-231 cells, 5.14 µM in MDA-MB-231/DOX cells, 0.36 µM in MDA-MB-468 cells and 0.22 µM in HCC1937 cells, the MDM2/MDMX inhibitor 33.16 nM in MDA-MB-231 cells, 38.28 nM in MDA-MB-231/DOX cells, 41.49 nM in MDA-MB-468 cells and 36.78 nM in HCC1937 cells. The representative charts (a) and quantified data (b) of transwell are separately shown. The values presented are indicative of the mean ± SD for each group. *P < 0.05, **P < 0.01, ***P < 0.001 (n = 3) vs. the control group, the DOX only group or the MDM2/MDMX inhibitor group.