Figure 2.

ZCL compounds regulate microspike formation. Swiss 3T3 cells were starved ON then preincubated with ZCL367 (50 μM) for 2 h. Bradykinin (100 ng/mL) was used to activate Cdc42/Rac1 for 20 m. Cells were also treated with ZCL278 (50 μM) for comparison. Cells were fixed and stained with phalloidin. Boxes are magnifications of membrane ruffling and highlighted by →. Circles are magnifications of microspikes and highlighted by ▲. Asterisks (*) highlight diminished stress fibers.